Human chorionic gonadotropin (HCG)

During ovulation, Novarel stimulates the release of the egg by promoting normal egg development in the ovary. Women use a hormone called human chorionic gonadotropin (HCG) to induce ovulation and treat infertility, while men use it to enhance sperm production.

It helps an egg develop naturally in a woman's ovaries and guides the eggs' release during ovulation. Additionally, HCG is used in young boys whose testicles have not yet dropped naturally into the scrotum. A pituitary gland disorder is responsible for this. The medication guide does not cover all the potential uses of HCG.


The Novarel injection is administered under the skin or to a muscle. To properly use this at home, your healthcare provider, nurse, or pharmacist will recommend how and where to inject the medication. When self-injecting this medicine, you should only do so if you are fully knowledgeable of how to administer the injection and how to properly dispose of needles and syringes.

Boys can develop early puberty when exposed to HCG. A boy taking this medicine should see a doctor if he exhibits early signs of puberty, such as increased sweating or acne a deeper voice, etc.

The following symptoms may indicate you have a blood clot, consult your doctor immediately:

  • pain,
  • warmth,
  • redness,
  • numbness,
  • tingling in your arm or leg;
  • confusion,
  • extreme dizziness, or
  • severe headache.

It is possible that some women may develop a condition called ovarian hyperstimulation syndrome (OHSS), often after the first cycle of treatment. OHSS can have severe consequences. You should see your doctor immediately if you experience these:

  • severe pelvic pain,
  • swelling of the hands or legs,
  • stomach pain and swelling,
  • shortness of breath,
  • weight gain,
  • diarrhea,
  • nausea or vomiting,
  • Decreased urinating

Precautions for pregnant women

There is a chance that you may have multiple pregnancies (twins, triplets, quadruplets, etc.) if you take this medicine. The risks associated with multiple pregnancies are high for the mother as well as the newborn. Follow any special instructions your doctor may give you during your pregnancy.

Although HCG can assist in pregnancy, this drug is classified as pregnancy category X by the FDA. As a result, using the medication when you are pregnant may result in birth defects. If you are pregnant, you should not take this medication. If you become pregnant while undergoing treatment, inform your doctor immediately. There is no information on whether HCG is passed through breast milk. If you are breastfeeding, don't use HCG without consulting your doctor.

Before taking this medicine

Using this medication may be unsafe if you have ever had an allergic reaction to HCG, or if:

  • The onset of early puberty (also known as precocious puberty);
  • Cancer caused by hormones (such as prostate cancer).

This medication may need to be adjusted or you may need to undergo special testing if you have any of the following conditions:

  • thyroid or adrenal gland disorder;
  • an ovarian cyst;
  • premature puberty;
  • cancerous tumors of the ovary, breast, uterus, prostate, pituitary gland or hypothalamus,
  • undiagnosed uterine bleeding;
  • heart disease;
  • kidney disease;
  • epilepsy;
  • migraines; or
  • asthma.

Other drugs might also interact with HCG. Your doctor needs to know about all the medications you are taking, including over-the-counter medications. Vitamins, minerals, herbal products, and medications prescribed by other doctors are included in this category. Tell your doctor before beginning any new medication.

How to Use Novarel

Follow your doctor's exact instructions when you purchase HCG injections. The amount or duration of its use should not exceed the recommended amount. Be sure to follow all instructions on your prescription label.

Injecting HCG under the skin or into the muscle is a common method of administering it. It will be given to you by one of your healthcare providers, such as your doctor or nurse. It is possible to learn how to inject your medicine at home. If you are not familiar with the proper way of giving the injection and disposing of used needles and syringes, do not self-inject this injection.

Disposable needles should be used only once. Make sure to dispose of used needles in puncture-proof containers or another option is to ask your pharmacist. Children and pets should not have access to this container.

You must see your doctor regularly to make sure the medication is helping your condition. Make sure that you do not miss an appointment.

Several brands of HCG are in powdered form with a liquid that must be mixed together and drawn into the syringe. Others are packaged in one-dose prefilled syringes. You should not use the medication if the colors have changed, or the liquid contains any particles. Get a new prescription from your doctor.

Ensure the powder form of HCG is stored away from light, moisture, and heat at room temperature. It is important to keep the powder mixture in the refrigerator after mixing it with the liquid. In the case of HCG, throw away any mixed medicine you haven't used within 30 days of mixing.

Be sure to carefully follow the mixing, storage, and expiration instructions that come with your HCG brand. Please consult your doctor or pharmacist if you have questions about how long and at what temperature you can store your mixed medicine.

HCG side effects 

When you notice any of these signs of an allergic reaction, stop using HCG and seek medical attention immediately, such as hives, difficulty breathing; swelling of your face, lips, tongue, or throat.

In less severe cases, the following can occur:

  • headache;
  • restlessness or irritation;
  • water retention or mild swelling;
  • depression;
  • breast tenderness or swelling;
  • soreness, swelling, or irritation at the injection site.

A complete list of side effects is not available, and others may also occur. For medical advice about side effects, contact your doctor.

Missing a dosage

It is important to call your doctor if you miss an HCG dose.


If you believe you have taken too much of this medication, contact emergency medical assistance. There are no known adverse effects from excessive amounts of HCG. Do follow the above-mentioned precautions when you buy HCG injections.