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How Progynova Works In Hormone Replacement Therapy?

How Progynova Works In Hormone Replacement Therapy?

Progynova is a women sex hormone. The main and active substance of the medicine is estradiol valerat

What is Progynova? 

The medicine has the main active substance estradiol valerate. Progynova helps in hormone replacement therapy for the treatment of midlife crisis (menopausal). This problem occurs after the end of monthly bleeding, due to radiotherapy, or after surgical elimination of the ovaries (oophorectomy),. The medicine is prescribed only for short-term use. The estradiol valerate is a forerunner of the estradiol hormone. It is also called women's sex hormone. 

In the period of menopause, the production of estradiol in the ovaries reduces. However, menopause is natural a phenomenon. It generally becomes the reason for distressing symptoms, which are associated with the gradual decrease of the hormones secreted by the ovaries. The medicine retrieves the estradiol hormone that the body no longer produces itself and prevents or relieves signs such as sweats, hot flashes, sleep distortions, depressive moods, drowsiness, dizziness, headaches as well as vaginal burning and dryness. 

If you have not had a hysterectomy or uterus removed your health expert will give you another hormone progestogen to take along with this drug. This medicine does save you from pregnancy because it is not a contraceptive.

Things one should be aware of before using this medicine.

  • you have allergies to estradiol valerate or any of the co-ingredients of this drug. A cross-check check to confirm you can use this drug.
  • Case if you have undiagnosed and untreated vaginal bleeding.
  • Any type of tumor
  • Jaundice or severe liver diseases.
  • Have or had heart problems like stroke, heart attack, etc.
  • if you have a history of blood clotting
  • Increased level of fat in the blood.
  • Diabetes
  • Hear loss due to abnormal bone growth in the ear
  • If you have breast cancer
  • You use this drug if you are above 18 years of age.

How to use Progynova?

Carefully follow your health expert's advice. The information written on the leaflet can be slightly different from the expert advice so you have to follow your doctor's advice. If you have any further doubts or questions consult your health expert.

In case you are using other medicines: Discuss with your doctor or pharmacist if you are using any other drugs, including vitamins or supplements or any medicine, that you buy without a prescription.

Progynova can interact with other substances include;-

  • Antidiabetic, medicine, insulin, or other related medicines.
  • If you use grapefruit juice
  • Fungal infection medicines like itraconazole, voriconazole, ketoconazole, fluconazole
  • Medicines that work to treat Hepatitis C Virus (HCV) like telaprevir and boceprevir.
  • Some herbal medicines.
  • HIV medicines like nevirapine, nevirapine
  • Medicines that work to treat epilepsy such as barbiturates, primidone, hydantoins, topiramate, carbamazepine, oxcarbazepine,  felbamate
  • Medicine that works in treating high BP, stroke, chest pain, and irregular heartbeat.
  • Medicines that work to treat tuberculosis.

The above-listed substance can interact with this drug or can affect the effectiveness of these substances. You may need a change in doses or a change in medicine.

How much can I use Progynova?

It is a short-term medicine therefore do not take it for too long. Follow the advice of your healthcare expert for the dose and duration of the medicine.
You can not modify or alter the dose according to your requirements or ease.

Uses of Progynova

The Drug comes in different forms such as oral, injectable, and topical. However, it is a prescription drug used to treat signs of menopause including dryness of the vagina and hot flashes. It is also effectively working to treat problems in which the ovaries of a woman do not make enough estrogen naturally which is also known as hypoestrogenism. This can also be prescribed for several other areas, breast cancer or prostate cancer in combination with other cancer medicines

Adverse Effects of this medicine

Some of the undesirable effects of this medicine can be noticed in a few patients.

Some of the adverse effects are;-

  • gas
  • heartburn
  • weight gain or loss
  • hair loss
  • nausea
  • vomiting
  • constipation
  • headache
  • breast pain or tenderness
  • redness or irritation of the skin
  • swelling, redness, irritation, burning, or itching of the vagina
  • vaginal discharge
  • painful menstrual periods
  • anxiety
  • changes in mood
  • change in sexual desire
  • back, neck, or muscle pain
  • runny nose or congestion
  • cough
  • Skin darkening

Advantages of this medicine

HRT(Hormone placement therapy ) is to ease signs of menopause such as night sweats, hot flashes, mood swings, reduced sex drive, and vaginal dryness. Since the condition of menopause can last for many years, this medicine can make a big change to your day-to-day life and mood. Besides progesterone, estrogen is also an important hormone, used in this treatment. Take this treatment as long as your health expert prescribes you.

Habit Forming


Diet & Lifestyle Tips 

  • Go for daily exercise and physical activity to decrease hot flashes and enhance sleep. Besides this, a weight-lifting workout can help keep your bones strong. Yoga, aerobics, and other workouts like tai chi can give great help in relaxing the mind and body.
  • Wear loose and relaxed clothes before going to sleep and try to sleep in a cool, properly ventilated area. You can prevent these symptoms of night sweats and hot flashes by doing this. Sleep at least eight hours and keep your body and mind relaxed.
  • You have to avoid or limit the use of caffeinated beverages, liquor, and spicy food because these can trigger hot flashes.
  • Try to be stress-free and relaxed to better your mood swings due to hormonal imbalance.
  • Quit or avoid smoking because this will help to reduce hot flashes and also the risk of developing conditions like stroke, heart disease, and cancer.
  • Use vaginal lubricants or moisturizers to prevent vaginal dryness.

Disease/Condition Checklist


It refers to the decreased production of the natural female sex hormone, we know as estrogen. Hypoestrogenism is an umbrella term that is used for estrogen deficiency in different conditions. The abnormalities of this hormone may lead to bone loss, infertility, and lipid abnormalities.


Osteoporosis is a condition in which bones become so fragile. In this condition, too much bone is destroyed in the body, and the body produces relatively little bone. As a result, your bones become very weak and can break quite easily if you fall.

Hormone replacement therapy:

HTR treatment works to ease the signs of menopause. It works to change those hormones that are at a lower level as you hit menopause.

Safety Tips 


To avoid unhappening and unpleasant results say no to alcohol while using this medicine.


Progynova does not affect your ability to drive vehicles. Therefore you can drive safely.

In pregnancy:

This medicine or therapy is not recommended during the days of your pregnancy because it can harm the health of the unborn baby. Therefore do not take this during your pregnancy days.


Avoid the use of Progynova in case you are feeding because it can mix with your breast milk and contaminate the milk, eventually, this can hurt your baby's health.


A patient who is suffering from liver problems should use this drug under the guidance of a health expert. Take proper caution while using it.

Some of the frequently asked questions are:- 

What is the working mechanism of Progynova?

Doctors prescribe this medicine when the body does not make enough natural estrogen hormones. It acts by changing the normal functions of the hormone estrogen in the body and treating signs linked with menopause.

When should not give Progynova?

There a certain conditions in which you should not use Progynova like:-

  • If you have an allergy to peanuts
  • Unusual and unknown vaginal bleeding
  • If have had any type of cancer like the uterus or breast cancer
  • In case taking any other estrogen medicine
  • If you have problems with blood clotting.
  • History of heart attack or stroke
  • If Pregnant
  • Feeding a baby
  • If you have liver or kidney-related issues.

Can I use it if I am going for surgery?

No, you should not use this treatment at least for 4-6 weeks if you are having any surgery as it can increase the risk of blood clotting.
Inform your health expert about HRT.

Can this medicine become a reason for weight gain?

Gaining or losing weight is one of the very usual side effects of Progynova. This medicine can affect your weight either way. Therefore you should maintain a healthy lifestyle by doing exercise, yoga, and a balanced diet.

Who cannot take this medicine?

Patients, who are suffering from blood clotting, unknown vaginal bleeding, or any type of breast or uterus cancer can’t use it. Also, those who had or have heart issues like stroke, attack, etc.







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